Endocrine Abstracts

Introduction: Since the outbreak of the COVID-19 pandemic, several cases of pituitary apoplexy following a SARS-CoV-2 infection have been described in several countries. Here, we describe a case series of pituitary apoplexy occurring in the aftermath of a SARS-CoV-2 infection to alert physicians about possible neuro-endocrinological damage caused by the virus that can lead to visual sequelae and hypopituitarism.Methods: We retrospectively identified all ...

Hypocalcemia is a classic complication after total thyroidectomy, mostly due to post-operative hypoparathyroidism. However others factors, like vitamin D deficiency, may contribute to this hypocalcemia.Objective: To determine if vitamin D preoperative status influence early postoperative serum calcium levels after total thyroidectomy.Patients and methods: Seventy-nine patients (65 women/14 men), mean age 52.8 (±12.7), were inc...

Context: The long-term consequences of Covid-19 are unknown. Most patients experience persistent symptoms more than a month after the acute illness, including fatigue, dyspnea, memory loss, concentration disorder. The pituitary, the thyroid and the adrenal gland express the ACE-2 receptor, which is the cellular receptor for SARS-CoV-2, and could therefore be affected by the virus. However, the effect of Covid-19 on the hypothalamic-pituitary-adrenal-axis and hypothalamic-pitui...

Ipilimumab is an immunomodulating agent for the treatment of metastatic melanoma. Ipilimumab is a human mAb which works by inhibiting cytotoxic T-lymphocyte antigen 4 (CTLA-4).CTLA4 typically works to down-regulate the T-cell response and protects self-antigens from recognition by the immune system. Since the T-cells are no longer down-regulated by this antigen, they are allowed to proliferate, thereby helping to prevent melanoma tumor evasion. As a resu...

Introduction: Autoimmune thyroid disease (AITD) is a common disease. It arise due to interactions between genetic background and environmental factors. However this interactions remain unclear. As it induces other autoimmune diseases, parvovirus is an attractive candidate.Objective: To investigate the presence of parvoviral DNA in postoperative thyroid tissues.Materials and methods: We collect prospectively postoperative thyroid sp...

IntroductionThere is no consensus about biological targets in patients with central hypothyroidism (CH). The main objective of this work was to characterize our patients with CH.DesignWe conducted a retrospective study at the University Hospital of Amiens. In our center, patients with CH are considered “well substituted” if the free thyroxine (FT4) is in the upper half of the reference interval and ...

Calcium-sensing receptor gene (CASR) loss-of-function mutations lead to familial hypocalciuric hypercalcaemia (FHH), neonatal severe hyperparathyroidism, and primary hyperparathyroidism. FFH is characterized by mild hypercalcaemia, hypocalciuria, calcium clearance/creatinine clearance (CaCl/CrCl) <0.01, normal or high PTH level. Nevertheless the phenotype may vary (Thakker 2012). The aim of this work was to compare the phenotypes of patients bearing or not a pathogenic <em...

Context: Primary bilateral macronodular adrenal hyperplasia (PBMAH) with glucose-dependent insulinotropic polypeptide (GIP)-dependent Cushing’s syndrome is caused by ectopic expression of GIP receptor in the adrenal tissue. The bilateral nature of this adrenal disease suggests germline genetic predisposition. We aimed to identify the molecular driver event responsible for ectopic GIP receptor expression in PBMAH.Methods: We conducted an internationa...

Context: Paragangliomas and pheochromocytomas (PPGL) are rare neuroendocrine tumors, characterized by a strong genetic component. Indeed, up to 40% of patients carry a germline mutation in a PPGL susceptibility gene. In accordance with the international recommendations, genotyping of PPGL susceptibility genes is therefore proposed to all patients with PPGL, but it has actually never been shown whether the identification of a germline mutation in one PPGL susceptibility gene ch...